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Phenotypes Associated with This Genotype
Genotype
MGI:3693291
Allelic
Composition
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO/CMV-KRAS*G12C)9.1Msmi/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SFTPC-rtTA)5Jaw mutation (3 available)
Tg(tetO/CMV-KRAS*G12C)9.1Msmi mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• after 12 days of doxycycline (DOX) treatement, small, hyperplastic lung foci are detected; untreated mice have normal lungs
• after 5 weeks of DOX treatment, extensive epithelial hyperplasia of alveolar region of lung is observed; untreated mice have normal lungs
• alveolar lipoproteinosis is regularly found, indicating abnormal surfactant metabolism

neoplasm
• after 3 months treatment, visible macroscopic lesions are found; tumor incidence at 3 months is 55%, with multiplicity of 1.7 tumors/mouse
• lesions are <1mm in size
• early hyperplastic lesions are of alveologenic origin
• at 6 and 9 months DOX treatment, visible lesions increase in number; multiplicity is 10.2 and 12.5 tumors/mouse after 9 and 12 months, lower than Scgb1a1/KRAS bitransgenic mice; treated monotransgenic mice show no incidence
• when DOX treatment was stopped after 9 months, within 2 weeks only 4 tumors are visible on lung surface and by 1 month, no tumors are visible, and with minimal hyperplastic foci microscopically detectable, showing no proliferation (or apoptosis)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lung benign neoplasm DOID:3683 J:102839


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory