Phenotypes Associated with This Genotype

Genotype
MGI:3693212

• Allelic Composition: Bcl2^tm1Mpin/Bcl2^tm1Mpin; Tg(SFTPC-RAF1-BxB)1Urr/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung adenoma incidence ( J:79696 )

• 40% develop lung tumors at 2.5 months of age

decreased tumor incidence ( J:79696 )

• although mutants develop lung adenomas, they show a 6-8 fold delay in tumor incidence compared to single transgenic Tg(SFTPC-RAF1-BxB)1Urr mice

• exhibit an increase in the number of apoptotic cells and a decrease in the number of proliferating cells in lung ademonas

respiratory system

increased lung adenoma incidence ( J:79696 )

• 40% develop lung tumors at 2.5 months of age