Phenotypes Associated with This Genotype

Genotype
MGI:3693205

• Allelic Composition: Tg(SFTPC-RAF1-BxB)1Urr/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung adenoma incidence ( J:80895 )

• develop lung tumors within 1-2 months of age; confluent tumor development is observed within 5-7 months, accompanied by an 8-10-fold increase in lung tissue mass

• lesions are classified as multicentric alveolar adenomas developed from alveolar type II cells

• tumors consist of cuboid epithelial comparable to alveolar type II cells and show a glandular proliferation, lining the alveolar walls in a lepidic fashion

respiratory system

increased lung adenoma incidence ( J:80895 )

• develop lung tumors within 1-2 months of age; confluent tumor development is observed within 5-7 months, accompanied by an 8-10-fold increase in lung tissue mass

• lesions are classified as multicentric alveolar adenomas developed from alveolar type II cells

• tumors consist of cuboid epithelial comparable to alveolar type II cells and show a glandular proliferation, lining the alveolar walls in a lepidic fashion