About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3692945
Allelic
Composition
Tg(Tnfsf13b)1Fma/0
Genetic
Background
B6.Cg-Tg(Tnfsf13b)1Fma
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• B220hi/IgMhi B cell subset is greatly increased in transgenic mice (J:73711)
• IgM dull subset of B cells is larger in transgenic mice compared to control (J:73711)
• large IgMhi B cell subset is phenotypically different from the small IgMhi B cell subset in controls, resembling marginal zone B cells (J:73711)
• IgM dull subset of B cells is larger in transgenic mice compared to control (J:73711)
• B220hi/IgMhi B cell subset is greatly increased in transgenic mice (J:73711)
• large IgMhi B cell subset is phenotypically different from the small IgMhi B cell subset in controls, resembling marginal zone B cells (J:73711)
• a marked increase in some B cell subsets compared to wild-type is detected in 12 week old mice (J:114782)
• a marked increase in some B cell subsets compared to wild-type is detected in 12 week old mice (J:114782)
• presence of B-1a (CD5+) B cells are detected compared to controls (J:114782)
• presence of B-1a (CD5+) B cells are detected compared to controls (J:114782)
• a 3-fold increase in B-1b (CD5-) B cells (J:114782)
• a 3-fold increase in B-1b (CD5-) B cells (J:114782)
• there is an increased frequency of B220neg/lo, IgA+ plasma cells in lamina propria preparations (mutants 45.5% vs wild-type 14.4%) (J:114782)
• there is an increased frequency of B220neg/lo, IgA+ plasma cells in lamina propria preparations (mutants 45.5% vs wild-type 14.4%) (J:114782)
• numerous germinal centers are observed in B cell follicles of young transgenic mice compared to wild-type and aged transgenic mice (J:114782)
• numerous germinal centers are observed in B cell follicles of young transgenic mice compared to wild-type and aged transgenic mice (J:114782)
• splenic marginal zone is increased in size, particularly notable in aged mice (J:114782)
• splenic marginal zone is increased in size, particularly notable in aged mice (J:114782)
• mice exhibit elevated levels in both steady state and in response to antigen stimulation; at 12 weeks of age, IgA levels are increased 1500-fold over wild-type (22.7 mg/ml IgA vs 0.015 mg/ml in wild-type - hyper-IgA) (J:114782)
• augmented IgA staining is found in lamina propria of transgenic mice (J:114782)
• mice exhibit elevated levels in both steady state and in response to antigen stimulation; at 12 weeks of age, IgA levels are increased 1500-fold over wild-type (22.7 mg/ml IgA vs 0.015 mg/ml in wild-type - hyper-IgA) (J:114782)
• augmented IgA staining is found in lamina propria of transgenic mice (J:114782)

immune system
• 60% of mice over 12 months of age have severely inflamed salivary glands with large leukocytic infiltrates (J:73711)
• 60% of mice over 12 months of age have severely inflamed salivary glands with large leukocytic infiltrates (J:73711)
• IgM dull subset of B cells is larger in transgenic mice compared to control (J:73711)
• B220hi/IgMhi B cell subset is greatly increased in transgenic mice (J:73711)
• large IgMhi B cell subset is phenotypically different from the small IgMhi B cell subset in controls, resembling marginal zone B cells (J:73711)
• IgM dull subset of B cells is larger in transgenic mice compared to control (J:73711)
• B220hi/IgMhi B cell subset is greatly increased in transgenic mice (J:73711)
• large IgMhi B cell subset is phenotypically different from the small IgMhi B cell subset in controls, resembling marginal zone B cells (J:73711)
• a marked increase in some B cell subsets compared to wild-type is detected in 12 week old mice (J:114782)
• a marked increase in some B cell subsets compared to wild-type is detected in 12 week old mice (J:114782)
• presence of B-1a (CD5+) B cells are detected compared to controls (J:114782)
• presence of B-1a (CD5+) B cells are detected compared to controls (J:114782)
• a 3-fold increase in B-1b (CD5-) B cells (J:114782)
• a 3-fold increase in B-1b (CD5-) B cells (J:114782)
• there is an increased frequency of B220neg/lo, IgA+ plasma cells in lamina propria preparations (mutants 45.5% vs wild-type 14.4%) (J:114782)
• there is an increased frequency of B220neg/lo, IgA+ plasma cells in lamina propria preparations (mutants 45.5% vs wild-type 14.4%) (J:114782)
• numerous germinal centers are observed in B cell follicles of young transgenic mice compared to wild-type and aged transgenic mice (J:114782)
• numerous germinal centers are observed in B cell follicles of young transgenic mice compared to wild-type and aged transgenic mice (J:114782)
• splenic marginal zone is increased in size, particularly notable in aged mice (J:114782)
• splenic marginal zone is increased in size, particularly notable in aged mice (J:114782)
• mice exhibit elevated levels in both steady state and in response to antigen stimulation; at 12 weeks of age, IgA levels are increased 1500-fold over wild-type (22.7 mg/ml IgA vs 0.015 mg/ml in wild-type - hyper-IgA) (J:114782)
• augmented IgA staining is found in lamina propria of transgenic mice (J:114782)
• mice exhibit elevated levels in both steady state and in response to antigen stimulation; at 12 weeks of age, IgA levels are increased 1500-fold over wild-type (22.7 mg/ml IgA vs 0.015 mg/ml in wild-type - hyper-IgA) (J:114782)
• augmented IgA staining is found in lamina propria of transgenic mice (J:114782)
• most mice over 13 months of age show signs of severe nephritis (J:73711)
• most mice over 13 months of age show signs of severe nephritis (J:73711)

renal/urinary system
• proteinuria is detected only in a subset of 8-month old mice (J:114782)
• proteinuria is detected only in a subset of 8-month old mice (J:114782)
• most mice over 13 months of age show signs of severe nephritis (J:73711)
• most mice over 13 months of age show signs of severe nephritis (J:73711)
• IgA immune complexes are detected in majority of young and aged mice (J:114782)
• IgA immune complexes are detected in majority of young and aged mice (J:114782)
• IgA deposits are found in nearly all glomeruli, while deposits of each IgG, and IgM are also detected, while very little Ig deposition is found in wild-type kidneys (J:114782)
• IgA deposits are found in nearly all glomeruli, while deposits of each IgG, and IgM are also detected, while very little Ig deposition is found in wild-type kidneys (J:114782)
• significant IgA deposits are found specifically in kidney glomerular mesangium (J:114782)
• significant IgA deposits are found specifically in kidney glomerular mesangium (J:114782)
• in 8-month old mice, glomeruli are slightly enlarged and hypercellular (J:114782)
• in 8-month old mice, glomeruli are slightly enlarged and hypercellular (J:114782)

homeostasis/metabolism
• mice aged 12-15.5 months of age produce significantly less saliva compared to age-matched controls; this difference is not observed in mice aged 8-10 months (J:73711)
• mice aged 12-15.5 months of age produce significantly less saliva compared to age-matched controls; this difference is not observed in mice aged 8-10 months (J:73711)
• proteinuria is detected only in a subset of 8-month old mice (J:114782)
• proteinuria is detected only in a subset of 8-month old mice (J:114782)

digestive/alimentary system
• many mice over 13 months of age have enlarged salivary glands (J:73711)
• many mice over 13 months of age have enlarged salivary glands (J:73711)
• mice aged 12-15.5 months of age produce significantly less saliva compared to age-matched controls; this difference is not observed in mice aged 8-10 months (J:73711)
• mice aged 12-15.5 months of age produce significantly less saliva compared to age-matched controls; this difference is not observed in mice aged 8-10 months (J:73711)
• 60% of mice over 12 months of age have severely inflamed salivary glands with large leukocytic infiltrates (J:73711)
• 60% of mice over 12 months of age have severely inflamed salivary glands with large leukocytic infiltrates (J:73711)

endocrine/exocrine glands
• many mice over 13 months of age have enlarged salivary glands (J:73711)
• many mice over 13 months of age have enlarged salivary glands (J:73711)
• mice aged 12-15.5 months of age produce significantly less saliva compared to age-matched controls; this difference is not observed in mice aged 8-10 months (J:73711)
• mice aged 12-15.5 months of age produce significantly less saliva compared to age-matched controls; this difference is not observed in mice aged 8-10 months (J:73711)
• 60% of mice over 12 months of age have severely inflamed salivary glands with large leukocytic infiltrates (J:73711)
• 60% of mice over 12 months of age have severely inflamed salivary glands with large leukocytic infiltrates (J:73711)

tumorigenesis
• some mice (3 cases) have large submaxillary tumors which contain hyperplastic lymphoid tissue composed of activated B cells and numerous germinal centers; these abnormal aggregates of B lymphoid cells are found in lymphocytic infiltrates of some tumor-free mice (J:73711)
• some mice (3 cases) have large submaxillary tumors which contain hyperplastic lymphoid tissue composed of activated B cells and numerous germinal centers; these abnormal aggregates of B lymphoid cells are found in lymphocytic infiltrates of some tumor-free mice (J:73711)

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:73711


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory