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Phenotypes Associated with This Genotype
Genotype
MGI:3692929
Allelic
Composition
Tg(Tnfsf13b)1Fma/0
Genetic
Background
involves: C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• total numbers of T and B cells in bone marrow of transgenic mice is similar to control
• alterations in T cell numbers are present in transgenic mice
• absolute numbers of CD4 circulating T cells are reduced 50% compared to control; similar observations are made for CD8 T cell subset
• total number of T cells in spleen and MLN of transgenics is increased 2-fold
• transgenic mice have higher numbers of circulating lymphocytes than nontransgenic littermates, with numbers as high as 13000 lymphocytes/ul blood
• numbers of peripheral blood B cells are increased compared to controls; expansion of B cell compartment is observed, with global B cell activation
• total B cell number is 7-fold higher than in controls in spleen and mesenteric lymph nodes (MLN)
• mature B cell number in spleen and mesenteric lymph nodes (MLN) is increased compared to controls
• proportion of marginal zone B cells is increased compared to controls, while fraction of newly formed B cells is slightly decreased
• large numbers of plasma cells are present in spleen and mesenteric lymph nodes
• B cell/T cell ratios are increased in transgenics
• mice have enlarged spleens compared to control
• enlarged B cell follicles
• dendritic cells in T cell zone and marginal zone are reduced, compared to controls
• spleens contain large and numerous germinal centers in absence of immunization compared to control
• reduced periarteriolar lymphocyte sheath (or T cell area)
• all B cells in peripheral blood have increased MHC II and Bcl2 expression compared to controls, indicating some level of activation
• mice have hyperglobulinemia
• IgG levels are elevated (50 mg/ml vs ~5-8 mg/ml in controls)
• IgM levels are increased, but not as much as IgG levels
• 40-56% of CD4 or CD8 T cells are activated, with a CD44hi, L-selectinlo phenotype, compared to only 8-12% in control littermates

immune system
• alterations in T cell numbers are present in transgenic mice
• absolute numbers of CD4 circulating T cells are reduced 50% compared to control; similar observations are made for CD8 T cell subset
• total number of T cells in spleen and MLN of transgenics is increased 2-fold
• transgenic mice have higher numbers of circulating lymphocytes than nontransgenic littermates, with numbers as high as 13000 lymphocytes/ul blood
• numbers of peripheral blood B cells are increased compared to controls; expansion of B cell compartment is observed, with global B cell activation
• total B cell number is 7-fold higher than in controls in spleen and mesenteric lymph nodes (MLN)
• mature B cell number in spleen and mesenteric lymph nodes (MLN) is increased compared to controls
• proportion of marginal zone B cells is increased compared to controls, while fraction of newly formed B cells is slightly decreased
• large numbers of plasma cells are present in spleen and mesenteric lymph nodes
• B cell/T cell ratios are increased in transgenics
• mice have enlarged spleens compared to control
• enlarged B cell follicles
• dendritic cells in T cell zone and marginal zone are reduced, compared to controls
• spleens contain large and numerous germinal centers in absence of immunization compared to control
• reduced periarteriolar lymphocyte sheath (or T cell area)
• all B cells in peripheral blood have increased MHC II and Bcl2 expression compared to controls, indicating some level of activation
• mice have hyperglobulinemia
• IgG levels are elevated (50 mg/ml vs ~5-8 mg/ml in controls)
• IgM levels are increased, but not as much as IgG levels
• 40-56% of CD4 or CD8 T cells are activated, with a CD44hi, L-selectinlo phenotype, compared to only 8-12% in control littermates
• Peyer's patches are enlarged
• mice have increased levels of anti-IgG autoantibodies compared to controls; levels of rheumatoid factors (RF) and circulating immune complexes (CIC) are elevated

homeostasis/metabolism
• all transgenics display proteinuria

renal/urinary system
• all transgenics display proteinuria
• immunoglobulin deposition in kidneys is detected

growth/size/body
• mice have enlarged spleens compared to control


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory