hematopoietic system
N |
• total numbers of T and B cells in bone marrow of transgenic mice is similar to control
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• alterations in T cell numbers are present in transgenic mice
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• absolute numbers of CD4 circulating T cells are reduced 50% compared to control; similar observations are made for CD8 T cell subset
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• total number of T cells in spleen and MLN of transgenics is increased 2-fold
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• transgenic mice have higher numbers of circulating lymphocytes than nontransgenic littermates, with numbers as high as 13000 lymphocytes/ul blood
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• numbers of peripheral blood B cells are increased compared to controls; expansion of B cell compartment is observed, with global B cell activation
• total B cell number is 7-fold higher than in controls in spleen and mesenteric lymph nodes (MLN)
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• mature B cell number in spleen and mesenteric lymph nodes (MLN) is increased compared to controls
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• proportion of marginal zone B cells is increased compared to controls, while fraction of newly formed B cells is slightly decreased
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• large numbers of plasma cells are present in spleen and mesenteric lymph nodes
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• B cell/T cell ratios are increased in transgenics
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• mice have enlarged spleens compared to control
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• enlarged B cell follicles
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• dendritic cells in T cell zone and marginal zone are reduced, compared to controls
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• spleens contain large and numerous germinal centers in absence of immunization compared to control
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• reduced periarteriolar lymphocyte sheath (or T cell area)
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• all B cells in peripheral blood have increased MHC II and Bcl2 expression compared to controls, indicating some level of activation
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• mice have hyperglobulinemia
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• IgG levels are elevated (50 mg/ml vs ~5-8 mg/ml in controls)
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• IgM levels are increased, but not as much as IgG levels
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• 40-56% of CD4 or CD8 T cells are activated, with a CD44hi, L-selectinlo phenotype, compared to only 8-12% in control littermates
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immune system
• alterations in T cell numbers are present in transgenic mice
|
• absolute numbers of CD4 circulating T cells are reduced 50% compared to control; similar observations are made for CD8 T cell subset
|
• total number of T cells in spleen and MLN of transgenics is increased 2-fold
|
• transgenic mice have higher numbers of circulating lymphocytes than nontransgenic littermates, with numbers as high as 13000 lymphocytes/ul blood
|
• numbers of peripheral blood B cells are increased compared to controls; expansion of B cell compartment is observed, with global B cell activation
• total B cell number is 7-fold higher than in controls in spleen and mesenteric lymph nodes (MLN)
|
• mature B cell number in spleen and mesenteric lymph nodes (MLN) is increased compared to controls
|
• proportion of marginal zone B cells is increased compared to controls, while fraction of newly formed B cells is slightly decreased
|
• large numbers of plasma cells are present in spleen and mesenteric lymph nodes
|
• B cell/T cell ratios are increased in transgenics
|
• mice have enlarged spleens compared to control
|
• enlarged B cell follicles
|
• dendritic cells in T cell zone and marginal zone are reduced, compared to controls
|
• spleens contain large and numerous germinal centers in absence of immunization compared to control
|
• reduced periarteriolar lymphocyte sheath (or T cell area)
|
• all B cells in peripheral blood have increased MHC II and Bcl2 expression compared to controls, indicating some level of activation
|
• mice have hyperglobulinemia
|
• IgG levels are elevated (50 mg/ml vs ~5-8 mg/ml in controls)
|
• IgM levels are increased, but not as much as IgG levels
|
• 40-56% of CD4 or CD8 T cells are activated, with a CD44hi, L-selectinlo phenotype, compared to only 8-12% in control littermates
|
• Peyer's patches are enlarged
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• mice have increased levels of anti-IgG autoantibodies compared to controls; levels of rheumatoid factors (RF) and circulating immune complexes (CIC) are elevated
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homeostasis/metabolism
• all transgenics display proteinuria
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renal/urinary system
• all transgenics display proteinuria
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• immunoglobulin deposition in kidneys is detected
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growth/size/body
• mice have enlarged spleens compared to control
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