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Phenotypes Associated with This Genotype
Genotype
MGI:3692748
Allelic
Composition		 Tnftm3Gkl/Tnftm3Gkl
Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm3Gkl mutation (1 available); any Tnf mutation (46 available)
Zfp36tm1Pjb mutation (1 available); any Zfp36 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:114740 )
N
• up to 7 months of age, double mutants appear phenotypically normal and lack joint inflammation, cartilage erosion, and pannus formation compared to TNF-sufficient, Zpf36-null littermates which develop joint swelling and cachexia by 7 months
myeloid hyperplasia ( J:114740 )
• double mutants exhibit myeloid hyperplasia, similar to TNF-sufficient, Zpf36-null littermates

hematopoietic system
myeloid hyperplasia ( J:114740 )
• double mutants exhibit myeloid hyperplasia, similar to TNF-sufficient, Zpf36-null littermates

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory