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Phenotypes Associated with This Genotype
Genotype
MGI:3692746
Allelic
Composition
Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (26 available)
Tg(GFAP)10Mes mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• almost all die at around 30 days of age

nervous system
• two mutants exhibit seizure-like episodes before death
• at 24 days of age, exhibit increased Rosenthal fiber formation and higher levels of insoluble Gfap than either single mutant
• astrocytes are hypertrophied in the regions of brain that normally show high levels of Gfap expression

behavior/neurological
• two mutants exhibit seizure-like episodes before death

Mouse Models of Human Disease
OMIM ID Ref(s)
Alexander Disease; ALXDRD 203450 J:114689


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory