Mouse Genome Informatics
cx
    Gfaptm2Hgmn/Gfap+
Tg(GFAP)10Mes/0

involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• almost all die at around 30 days of age

nervous system
• two mutants exhibit seizure-like episodes before death
• at 24 days of age, exhibit increased Rosenthal fiber formation and higher levels of insoluble Gfap than either single mutant
• astrocytes are hypertrophied in the regions of brain that normally show high levels of Gfap expression

behavior/neurological
• two mutants exhibit seizure-like episodes before death

Mouse Models of Human Disease
OMIM IDRef(s)
Alexander Disease 203450 J:114689