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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in null embryonic fibroblasts (MEFs infected with adeno-cre to delete exon 1 of Pik3a), phosphorylation of Akt (PI3K activity measure) is reduced relative to wild-type MEFs when stimulated with insulin or insulin-like growth factor; phosphorylation in response to EGF or PDGF is also diminished at 60 minutes compared to wild-type cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/31/2026 MGI 6.24 |
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