About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3691282
Allelic
Composition
Myh6tm2Ces/Myh6+
Genetic
Background
involves: 129S/SvEv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh6tm2Ces mutation (0 available); any Myh6 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• show a gradual increase in left ventricle chamber size in some mutants by 12 weeks of age and in all mutants by 50 weeks of age
• exhibit a gradual development of dilated cardiomyopathy that is less pronounced than in Myh6tm1Ces heterozygotes
• isolated cardiac myocytes from 8-week old mutants have impaired contractile function, as indicated by reduced extent and rate of shortening, however to a lesser extent that in homozygotes

muscle
• exhibit a gradual development of dilated cardiomyopathy that is less pronounced than in Myh6tm1Ces heterozygotes
• isolated cardiac myocytes from 8-week old mutants have impaired contractile function, as indicated by reduced extent and rate of shortening, however to a lesser extent that in homozygotes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy 1EE DOID:0110453 OMIM:613252
J:114549


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory