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Phenotypes Associated with This Genotype
Genotype
MGI:3691134
Allelic
Composition		 Il23rtm1Dnax/Il23rtm1Dnax
Genetic
Background		 C57BL/6-Il23rtm1Dnax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23rtm1Dnax mutation (0 available); any Il23r mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:111568 )
N
• no phenotype was described except for the response to challenge with tumor cells
• inhibition of growth of injected B16F10 melanoma and LL2 lung carcinoma cells
• growth of PDV6 squamous carcinoma cells is reduced compared to wild-type but increased compared to mice unable to respond to IL12

homeostasis/metabolism
abnormal response/metabolism to endogenous compounds ( J:124591 )
• mice do not exhibit epidermal hyperplasia in response to intradermal IL-23 treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory