Phenotypes Associated with This Genotype

Genotype
MGI:3691131

• Allelic Composition: Gt(ROSA)26Sor^{tm1(MAML1)Wsp}/Gt(ROSA)26Sor⁺; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: CD-1 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

dermal cyst ( J:112093 )

• keratin cyst formation is observed

decreased body size ( J:112093 )

• generalized growth retardation is observed compared to controls

neoplasm

increased squamous cell carcinoma incidence ( J:112093 )

• mice develop spontaneous cutaneous SCC lesions, as well as dysplastic precursor lesions

limbs/digits/tail

abnormal tail morphology ( J:112093 )

• with aging, hyperkeratinization of tail is seen

integument

abnormal hair growth ( J:112093 )

• aberrant hair follicle cycling occurs

alopecia ( J:112093 )

• starting at 2-3 weeks, mice display hair and whisker loss; diffuse alopecia is observed

• at 10 months of age, alopecia has progressed almost to completion

abnormal dermal layer morphology ( J:112093 )

• hypoplastic dermis with increased cellularity is observed

• by 6 months of age, most mice develop hyperkeratotic cutaneous nodules, with all mutants exhibiting multiple lesions by 10 months of age

• examination of some nodules reveals papillomas or inflamed infundibular cyts

dermal cyst ( J:112093 )

• keratin cyst formation is observed

abnormal keratinocyte morphology ( J:112093 )

• cutaneous nodules show hyperproliferative keratinocytic lesions exhibiting cellular atypia and an invasive growth pattern