Analysis Tools
immune system
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• serum levels of T. muris-specific IgG1 are decreased compared to controls, IgG2a levels are increased, and total IgE is lower in infected mutants
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• under neutral and Th2 conditions, interferon gamma (Ifng)-producing cells increase in culture compared to controls; under Th1 conditions, there is no change in percentage of Ifng-producing cells
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• Th2 cell differentiation is impaired in culture compared to control CD4 trangenic mice
• under Th2 cell conditions, percentage of T cells expressing Il-4 is lower than in control cultures
• Th2 cytokine production is lower in mice after inoculation with T. muris (helminth)
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• mice are resistant to Leishmania major infection; parasitic replication is controlled and lesions are resolved compared to BALB/c controls
• lymph node cells produce abundant amounts of Ifng
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• mutants are unable to fight infection by T. muris, a helminthic pathogen
• Th2-dependent goblet cell and mucin responses are absent at day 21 after infection
• mice have a higher worm burden than control CD4 transgenic mice; at 32 days after inoculation, infection is still present
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hematopoietic system
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• serum levels of T. muris-specific IgG1 are decreased compared to controls, IgG2a levels are increased, and total IgE is lower in infected mutants
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• under neutral and Th2 conditions, interferon gamma (Ifng)-producing cells increase in culture compared to controls; under Th1 conditions, there is no change in percentage of Ifng-producing cells
|
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• Th2 cell differentiation is impaired in culture compared to control CD4 trangenic mice
• under Th2 cell conditions, percentage of T cells expressing Il-4 is lower than in control cultures
• Th2 cytokine production is lower in mice after inoculation with T. muris (helminth)
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