Phenotypes Associated with This Genotype

Genotype
MGI:3690997

• Allelic Composition: Cd3e^tm1.1Lov/Cd3e^tm1.1Lov; Trdc^tm1Mal/Trdc^tm1Mal
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal double-negative T cell morphology ( J:112658 )

• T cells do not progress beyond the DN3 stage; expression of Tcr gamma/delta heterodimers is absent on DN3 cells

• pool of preselection cells expressing Tcr beta chains makes up ~16% of DN3 cells

immune system

abnormal double-negative T cell morphology ( J:112658 )

• T cells do not progress beyond the DN3 stage; expression of Tcr gamma/delta heterodimers is absent on DN3 cells

• pool of preselection cells expressing Tcr beta chains makes up ~16% of DN3 cells