Phenotypes Associated with This Genotype

Genotype
MGI:3690622

• Allelic Composition: Fga^tm1Jld/Fga^tm1Jld; Plg^tm1Jld/Plg^tm1Jld
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss * CF-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:36591 )

N • show rescue from the early morbidity and premature death seen in single Plg homozygotes and show no signs of weight loss or wasting

homeostasis/metabolism

abnormal blood coagulation ( J:36591 )

• shortly after birth, a small fraction of neonates show peritoneal bleeding from which they generally recover, indicating lack of clotting function

• exhibit distinctly larger deposits of dried blood at wound margins and scabs of wounds appear initially less stable than in controls and resumed bleeding is occasionally apparent

abnormal wound healing ( J:36591 )

• exhibit distinctly larger deposits of dried blood at wound margins, however do not exhibit any of the wound healing defects seen in single Plg homozygotes

• scabs of wounds appear initially less stable than in controls and resume bleeding is occasionally apparent

liver/biliary system

abnormal liver morphology ( J:36591 )

• 6% (1 of 17) show hemorrhagic organized liver lesion

• 6% (1 of 17) show dystrophic calcification in liver

focal hepatic necrosis ( J:36591 )

• 41% (7 of 17) show sporadic necrotic liver foci

immune system

immune system phenotype ( J:36591 )

N • exhibit rescue of the various ulcerations and lesions seen in single Plg homozygotes

digestive/alimentary system

abnormal duodenum morphology ( J:36591 )

• 6% (1 of 17) show dystrophic calcification in duodenum