Phenotypes Associated with This Genotype

Genotype
MGI:3690619

• Allelic Composition: Kitl^Sl/Kitl^Sl-d
• Genetic Background: involves: C3H * C57BL/6 * DBA/2J * WC

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased mast cell number ( J:6084 )

• in early postnatal mice, mast cell number in skin is ~4% of wild-type number

• adult mice have <1% of numbers in wild-type mice

• no mast cells are detected in stomachs and mesenteries of adult mutants; none are found in cecum, bone marrow, spleen, thymus, heart, lung, kidney, liver or brain in mutants of various ages

immune system

decreased mast cell number ( J:6084 )

• in early postnatal mice, mast cell number in skin is ~4% of wild-type number

• adult mice have <1% of numbers in wild-type mice

• no mast cells are detected in stomachs and mesenteries of adult mutants; none are found in cecum, bone marrow, spleen, thymus, heart, lung, kidney, liver or brain in mutants of various ages

abnormal response to transplant ( J:6084 )

• after receiving skin grafts from Kit/Kit donors, a significant increase in mast cell number in skin is seen, compared no increase observed in reciprocal transplant