Phenotypes for Fas Mog MGI:3690541 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fas^tm1Cgn/Fas^tm1Cgn Mog^tm1(cre)Gkl/Mog⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^tm1Cgn mutation (1 available); any Fas mutation (82 available)
Mog^tm1(cre)Gkl mutation (1 available); any Mog mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:114741 )

N	• the fraction of B220+ T cells in the lymph nodes and the thymic distribution of CD4/CD8 cells are similar to wild-type

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:114741 )

• reduction in the onset and severity, but not incidence, of experimental autoimmune encephalomyelitis (EAE) induced by injection of MOG p35-55

• demyelination induced by injection of MOG p35-55 is reduced by about 70% compared to wild-type

• perivascular and parenchymal infiltration by T lymphocytes and macrophages is also reduced after induction of EAE

• mild reduction in oligodendrocyte apoptosis after EAE induction

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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