Phenotypes Associated with This Genotype

Genotype
MGI:3690368

• Allelic Composition: Apoe^tm1Bres/Apoe^tm1Bres
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gross appearance of aortic arches of Apoe^tm1Bres/Apoe^tm1Bres, Plg^tm1Jld/Plg^tm1Jld and Apoe^tm1Bres/Apoe^tm1Bres Plg^tm1Jld/Plg^tm1Jld mice

cardiovascular system

atherosclerotic lesions ( J:42927 )

• 57 of 63 display aortic lesion at 18 to 25 weeks of age

• lesions contain fibrinogen deposits

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:42927 )

• small decrease in high density lipoprotein cholesterol

increased circulating cholesterol level ( J:42927 )

increased circulating triglyceride level ( J:42927 )