Phenotypes Associated with This Genotype

Genotype
MGI:3690235

• Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:68069 )

• tail injected lymphocytes derived from homozygotes enter thymus 10-20 times less efficiently than controls

• migration to peripheral lymph nodes is delayed initially, but is balanced out in 24 hours

• lymphocyte migration to spleen is similar in mutant and control

abnormal CD4-positive, alpha beta T cell morphology ( J:68069 )

• CD4+ T cells do not have a CD25^low+ population

abnormal CD8-positive, alpha beta T cell morphology ( J:68069 )

• CD8+ T cells do not have a CD25^low+ population

abnormal neutrophil physiology ( J:94850 )

• very few neutrophils emigrate from the venules after intrascrotal administration of MIP-2 chemokine

• normal circulating leukocyte numbers

• decreased neutrophil adhesion and emigration in response to MIP-2

• normal ability of emigrated neutrophils to migrate through the tissue

• reduced neutrophil adhesion and emigration in chimeric mice whose endothelium lacks CD44

• reduced emigration in chimeric mice whose leukocyte lacks CD44

hematopoietic system

hematopoietic system phenotype ( J:110964 )

N • normal B cell maturation in the bone marrow of mutant mice

N • normal B cell subsets in the spleen of mutant mice

N • normal in-vitro activation pattern of mutant splenic B cells after stimulation with LPS, anti-IgM/IL-4 or anti-CD40/IL-4

abnormal leukocyte migration ( J:68069 )

• tail injected lymphocytes derived from homozygotes enter thymus 10-20 times less efficiently than controls

• migration to peripheral lymph nodes is delayed initially, but is balanced out in 24 hours

• lymphocyte migration to spleen is similar in mutant and control

abnormal CD4-positive, alpha beta T cell morphology ( J:68069 )

• CD4+ T cells do not have a CD25^low+ population

abnormal CD8-positive, alpha beta T cell morphology ( J:68069 )

• CD8+ T cells do not have a CD25^low+ population

abnormal neutrophil physiology ( J:94850 )

• very few neutrophils emigrate from the venules after intrascrotal administration of MIP-2 chemokine

• normal circulating leukocyte numbers

• decreased neutrophil adhesion and emigration in response to MIP-2

• normal ability of emigrated neutrophils to migrate through the tissue

• reduced neutrophil adhesion and emigration in chimeric mice whose endothelium lacks CD44

• reduced emigration in chimeric mice whose leukocyte lacks CD44

cardiovascular system

choroidal neovascularization ( J:154560 )

• increased choroidal neovascularization volume after laser injury

• enhanced hyaluronan accumulation on day 7 after laser injury

• increase in macrophage infiltration on day 3 after laser injury

vision/eye

choroidal neovascularization ( J:154560 )

• increased choroidal neovascularization volume after laser injury

• enhanced hyaluronan accumulation on day 7 after laser injury

• increase in macrophage infiltration on day 3 after laser injury

cellular

abnormal leukocyte migration ( J:68069 )

• tail injected lymphocytes derived from homozygotes enter thymus 10-20 times less efficiently than controls

• migration to peripheral lymph nodes is delayed initially, but is balanced out in 24 hours

• lymphocyte migration to spleen is similar in mutant and control