Analysis Tools
mortality/aging
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• die suddenly beginning at around 11 weeks of age when fed an atherogenic diet, compared to no increase in mortality in Apoe homozyous controls
• mutants that die suddenly show myocardial infarcts, stenoses, and total occlusions of proximal coronary arteries
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cardiovascular system
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• in a longer atherogenic diet study, develop severe occlusive proximal coronary artery disease and extensive myocardial infarcts
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• after 10 weeks on an atherogenic diet, exhibit increased atherosclerosis compared to controls (Apoe homozygotes) as indicated by increased intimal area in aortic root sections and sudanophilic area on pinned aortas
• after 10 weeks on an atherogenic diet, exhibit dilated aortic roots and increased medial destruction compared to controls
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• develop occlusive coronary artery disease
(J:101486)
• in a longer atherogenic diet study, develop severe occlusive proximal coronary artery disease
(J:102208)
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• exhibit significantly more collagenous scar formation in hearts at 15-weeks of age than single Apoe homozygotes
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• hearts are larger than in single Apoe homozygotes at 15, but not 3, weeks of age
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• hearts show more inflammatory cells, mostly macrophages, than single Apoe homozygotes
• accumulation of macrophages in hearts occurs as early as 5 weeks of age, before the onset of cardiac fibrosis or occlusive coronary artery disease
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immune system
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• hearts show more inflammatory cells, mostly macrophages, than single Apoe homozygotes
• accumulation of macrophages in hearts occurs as early as 5 weeks of age, before the onset of cardiac fibrosis or occlusive coronary artery disease
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growth/size/body
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• hearts are larger than in single Apoe homozygotes at 15, but not 3, weeks of age
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