Phenotypes for Pot1a MGI:3690027 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pot1a^{Gt(RRA096)Byg}/Pot1a^{Gt(RRA096)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pot1a^{Gt(RRA096)Byg} mutation (0 available); any Pot1a mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:112185 )

• cultured embryos die around E6.5

prenatal lethality, complete penetrance ( J:112185 )

• no homozygous offspring are generated from heterozygous crosses

embryo

absent inner cell mass ( J:112185 )

• cultured E1.5-3.5 embryos fail to form an inner cell mass

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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