Phenotypes Associated with This Genotype

Genotype
MGI:3689964

• Allelic Composition: Tg(Myh6-Mmp2*V107G)712Ajb/0
• Genetic Background: involves: 129/Sv * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardium layer morphology ( J:105703 )

• myocardium shows fibroblasts with abundant rough ER, suggesting some underlying fibrosis in trabeculae, although show no gross fibrosis

abnormal myocardial trabeculae morphology ( J:105703 )

• trabeculae tend to be larger than in wild-type

decreased cardiac muscle contractility ( J:105703 )

• both intact and skinned trabeculae show impaired active force generation compared to wild-type, indicating reduced contractile function, however systolic blood pressure and heart rate are normal

• inotropic responses to increases of bath calcium concentrations, pacing frequency, and isoproterenol are reduced compared to wild-type

• skinned trabeculae have about 50% reduction of force development compared to wild-type

abnormal myocardial fiber physiology ( J:105703 )

• unstimulated trabeculae have greater passive force at increased sarcomere length compared to wild-type, indicating increased myocardial stiffness

muscle

abnormal myocardium layer morphology ( J:105703 )

• myocardium shows fibroblasts with abundant rough ER, suggesting some underlying fibrosis in trabeculae, although show no gross fibrosis

abnormal myocardial trabeculae morphology ( J:105703 )

• trabeculae tend to be larger than in wild-type

decreased cardiac muscle contractility ( J:105703 )

• both intact and skinned trabeculae show impaired active force generation compared to wild-type, indicating reduced contractile function, however systolic blood pressure and heart rate are normal

• inotropic responses to increases of bath calcium concentrations, pacing frequency, and isoproterenol are reduced compared to wild-type

• skinned trabeculae have about 50% reduction of force development compared to wild-type