Phenotypes Associated with This Genotype

Genotype
MGI:3689930

• Allelic Composition: Tg(UCP3,UCP2)1Ful/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

improved righting response ( J:113539 )

• regaining of righting reflex is quicker on days 2, 3, and 4 of ethanol injections in UCP2-overexpressing mice compared to wild-type controls but on day 5, latencies are the same between genotypes

abnormal locomotor behavior ( J:113539 )

• mice recover and resume locomotion more quickly than wild-type on days 2, 3, and 4 of ethanol injections, compared to wild-type but on day 5, latencies are the same between genotypes

decreased thermal nociceptive threshold ( J:113539 )

• prior to ethanol injection, on first day of training, transgenic mice move away from hot plate at same pace as controls; 4 hours after ethanol treatment on day 1 and before and after ethanol injection on day 5 of treatment, mutants withdraw more rapidly from hot plate than control mice