Phenotypes Associated with This Genotype

Genotype
MGI:3689916

• Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx
• Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased microglial cell number ( J:112713 )

• numbers of microglial cells 23% lower than controls after epileptic stimulation

increased circulating tumor necrosis factor level ( J:45147 )

• two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered

decreased inflammatory response ( J:45147 )

• decreased pulmonary neutrophil accumulation in response to intranasal instillation of M. faeni as compared to control, however monocyte and lymphocyte levels are comparable to control

decreased susceptibility to endotoxin shock ( J:45147 )

• exhibits resistance to a lethal LPS dose plus hepatoxin D-gal (increases sensitivity to LPS)

lung inflammation ( J:120174 )

• lower levels of Il5, Il12, Il13, and Ifn-gamma in broncho-alveolar lavage fluid

• reduced numbers of T-alpha,beta cells in broncho-alveolar lavage fluid

increased susceptibility to bacterial infection ( J:45147 )

• 100% of mice succumb to a sublethal dose of Listeria monocytogenes 4 days post-infection

homeostasis/metabolism

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:78637 )

• 63% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)

increased circulating tumor necrosis factor level ( J:45147 )

• two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered

hematopoietic system

decreased microglial cell number ( J:112713 )

• numbers of microglial cells 23% lower than controls after epileptic stimulation

liver/biliary system

abnormal oval cell physiology ( J:66448 )

• reduced oval cell response to a choline deficient diet and ethionine in the drinking water

neoplasm

increased skin papilloma incidence ( J:89088 )

• development after DMPA/TPA treatment is reduced

decreased tumor incidence ( J:66448 )

• lower incidence of tumors after 9 months on a choline deficient diet and ethionine in the drinking water

nervous system

decreased microglial cell number ( J:112713 )

• numbers of microglial cells 23% lower than controls after epileptic stimulation

abnormal nervous system physiology ( J:112713 )

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:78637 )

• 63% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)

abnormal neuron proliferation ( J:112713 )

• 25% increase in the number of BrdU+ mature neurons in the dentate subgranular zone/granule cell layer

abnormal glutamate-mediated receptor currents ( J:152590 )

• increased glutamate currents

respiratory system

lung inflammation ( J:120174 )

• lower levels of Il5, Il12, Il13, and Ifn-gamma in broncho-alveolar lavage fluid

• reduced numbers of T-alpha,beta cells in broncho-alveolar lavage fluid

abnormal airway responsiveness ( J:120174 , J:143836 )

• fail to develop airway hyper responsiveness after "OVA" sensitization (J:120174)

abnormal respiratory mechanics ( J:143836 )

• peak inspiratory pressure is not affected by 2 hours of high stretch ventilation whereas controls experience rapid increases after 80-90 minutes

integument

increased skin papilloma incidence ( J:89088 )

• development after DMPA/TPA treatment is reduced

cellular

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:78637 )

• 63% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)

abnormal neuron proliferation ( J:112713 )

• 25% increase in the number of BrdU+ mature neurons in the dentate subgranular zone/granule cell layer