Phenotypes Associated with This Genotype

Genotype
MGI:3689872

• Allelic Composition: BY367451^tm1.1Mdk/BY367451⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:112937 )

• rotarod deficits are apparent but not significant at 18 weeks

• loss of motor coordination becomes significant at 24 weeks of age

abnormal gait ( J:112937 )

• appears by 4 weeks of age

• longer stride time only

• both fore and hind paws are affected but more pronounced in hind paws

nervous system

thin cerebellar molecular layer ( J:112937 )

• layer normal at 6 weeks but definitely thinner at 24 weeks of age

• dendritic atrophy of Purkinje cells seen but Purkinje cells themselves display an overall normal morphology