Phenotypes Associated with This Genotype

Genotype
MGI:3689728

• Allelic Composition: Myl2^tm1(cre)Krc/Myl2⁺; Ptk2^tm1.1Guan/Ptk2^tm1.1Guan
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardium layer morphology ( J:105371 )

abnormal myocardial fiber morphology ( J:105371 )

• cardiomyocytes of older mutants (9 months of age) exhibit increased length but not width

disorganized myocardium ( J:105371 )

• myocardium of older mutants (9 months of age) shows disorganized myofibrils with increased nonmyofibrillar space filled with swelled mitochondria

cardiac hypertrophy ( J:105371 )

• develop eccentric cardiac hypertrophy (normal left ventricle wall thickness and increased left chamber dimension) upon stimulation with angiotensin II or pressure overload by transverse aortic constriction, exhibiting an increase in heart/body weight ratios and elevated markers of cardiac hypertrophy

dilated heart left ventricle ( J:105371 )

• older mutants develop spontaneous cardiac chamber dilation

cardiac interstitial fibrosis ( J:105371 )

• develop multifocal interstitial fibrosis upon stimulation with angiotensin II

muscle

abnormal myocardium layer morphology ( J:105371 )

abnormal myocardial fiber morphology ( J:105371 )

• cardiomyocytes of older mutants (9 months of age) exhibit increased length but not width

disorganized myocardium ( J:105371 )

• myocardium of older mutants (9 months of age) shows disorganized myofibrils with increased nonmyofibrillar space filled with swelled mitochondria

growth/size/body

cardiac hypertrophy ( J:105371 )

• develop eccentric cardiac hypertrophy (normal left ventricle wall thickness and increased left chamber dimension) upon stimulation with angiotensin II or pressure overload by transverse aortic constriction, exhibiting an increase in heart/body weight ratios and elevated markers of cardiac hypertrophy

cellular

cardiac interstitial fibrosis ( J:105371 )

• develop multifocal interstitial fibrosis upon stimulation with angiotensin II