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Phenotypes Associated with This Genotype
Genotype
MGI:3689506
Allelic
Composition
Nodaltm4Rob/Nodaltm4Rob
Genetic
Background
involves: 129/Sv * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm4Rob mutation (0 available); any Nodal mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos die late in gestation or at birth due to spectrum of complex defects
• only 50% of homozygotes survive to term; remainder die late in gestation

cardiovascular system
• ~50% of homozygotes die late in gestation or at birth from spectrum of defects including heart abnormalities

craniofacial
• ~50% of homozygotes die late in gestation or at birth from spectrum of defects including craniofacial defects


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/20/2026
MGI 6.24
The Jackson Laboratory