Phenotypes Associated with This Genotype

Genotype
MGI:3689415

• Allelic Composition: Ctnnb1^tm1Max/Ctnnb1^tm2Kem; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb development ( J:114494 )

• at E16.5, clear zones of hypertrophy are visible in limbs compared to controls

skeleton

arrested osteoblast differentiation ( J:114494 )

• in mutant tibia, no Oc+ osteoblasts are detected, indicating failure of osteoblast progression to terminal osteoblasts

abnormal cartilage morphology ( J:114494 )

• hypertrophic chondrocytes line the periosteal region in addition to the normal growth plate

abnormal bone ossification ( J:114494 )

• membranous bone cranial ossification centers are absent at E18.5

• ossification in mutant periosteum of the tibia is absent

abnormal bone mineralization ( J:114494 )

• at E18.5, mutant limbs show absence of mineralized bone matrix compared to wild-type embryos and remaining mineralization is associated with hypertrophic chondrocytes; there appears to be complete loss of bone deposition

cellular

arrested osteoblast differentiation ( J:114494 )

• in mutant tibia, no Oc+ osteoblasts are detected, indicating failure of osteoblast progression to terminal osteoblasts