Phenotypes Associated with This Genotype

Genotype
MGI:3689409

• Allelic Composition: Cftr^tm1Unc/Cftr^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:44904 )

• Background Sensitivity: reduced relative to homozygotes on a congenic C57BL/6J background

• at P20 survival is 15.5% of all live births

respiratory system

respiratory system phenotype ( J:44904 )

N • Background Sensitivity: at 6 months of age bronchiolar and alveolar surfaces appear similar to wild-type as does the amount of acidic mucopolysacharides in material lining the airways and the proportion of non-ciliated cells in the broncheolar epithlium, unlike in homozygotes on a congenic C57BL/6J background

N • lung compliance corrected for body weight is similar to wild-type

abnormal vital capacity ( J:44904 )

• forced vital capacity per kg body weight is reduced compared to wild-type mice

decreased respiratory epithelial chloride transmembrane transport ( J:44904 )

• elevated negative basal nasal potential difference and absence of response to imposition of a luminally directed Cl- gradient

growth/size/body

postnatal growth retardation ( J:44904 )

• Background Sensitivity: less severe than in homozygous mice on a congenic C57BL/6J background