Phenotypes Associated with This Genotype

Genotype
MGI:3689355

• Allelic Composition: Tg(Ins2-Ccl19)2Cys/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:77238 )

• only small and medium-sized infiltrates develop, and become prominent only at >4 months of age

• fewer and smaller pancreatic infiltrates that are often observed in association with large blood vessels are observed compared to Ccl21b transgenics; B cells are found in greatest numbers in infiltrates, and CD4 T cells are more frequent than CD8 in pancreata of older mice

• infiltrates are less organized than in Ccl21b transgenic mice

• gp38+, BP3+, and ER-TR7+ stromal cell networks appear in infiltrates

• infiltrates display an invasive phenotype with individual T cells frequently seen in the islet cell mass; this is more apparent than in Ccl21b transgenic mice

immune system

abnormal lymph organ development ( J:77238 )

• results in development of high endothelial venules (HEVs) in the lymphoid tissue which are characterized by thick endothelium and addressin expression is seen