Phenotypes for Mc1r MGI:3689211 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mc1r^e/Mc1r^e
Genetic Background	involves: C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1r^e mutation (4 available); any Mc1r mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal touch/ nociception ( J:112815 )

• mutant females and males display reduced pain sensitivity

abnormal pain threshold ( J:112815 )

• males display significantly higher latencies than females for the 49 degree water tail withdrawal test

analgesia ( J:112815 )

• 6-10 week old females and males display increased analgesic responsiveness to morphine-6-glucuronide when challenged with thermal nociception

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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