Phenotypes Associated with This Genotype

Genotype
MGI:3689058

• Allelic Composition: Tg(CMV-Abcc9)1Ajo/?
• Genetic Background: either: (involves: BALB/c * CBA) or (involves: BALB/c * C57BL/6J * CBA)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber physiology ( J:111456 )

• cardiomyocytes respond to hypoxia with shortening of action membrane potential and are more resistant to hypoxia than controls, with 90.9% of cells surviving the 60-min long hypoxia compared to only 23.5% of control cells

abnormal response to cardiac infarction ( J:111456 )

• hearts acquire resistance to ischemia-reperfusion injury

decreased myocardial infarct size ( J:111456 )

• size of myocardial infarction is dramatically smaller (5.3% of the area at risk zone compared to 21.2% in wild-type)

muscle

abnormal sarcolemma morphology ( J:111456 )

• exhibit an increased number of sarcolemmal K_ATP channels in hearts

homeostasis/metabolism

abnormal response to cardiac infarction ( J:111456 )

• hearts acquire resistance to ischemia-reperfusion injury

decreased myocardial infarct size ( J:111456 )

• size of myocardial infarction is dramatically smaller (5.3% of the area at risk zone compared to 21.2% in wild-type)