Phenotypes Associated with This Genotype

Genotype
MGI:3688894

• Allelic Composition: Cd74^tm2Liz/Cd74^tm2Liz
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-2 secretion ( J:72243 )

• T cells from immunized mice secrete less Il-2 than wild-type cells, but show a similar proliferative response

increased susceptibility to experimental autoimmune encephalomyelitis ( J:72243 )

• direct immunization with p35-55 results in development of experimental autoimmune encephalitis (EAE); after initial onset of EAE, disease course is more severe than in wild-type and 2-fold greater than in invariant chain isoform p41 mutants