Phenotypes Associated with This Genotype

Genotype
MGI:3688719

• Allelic Composition: Spi1^tm2.1Dgt/Spi1^tm2.1Dgt
• Genetic Background: B6.Cg-Spi1^tm2.1Dgt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:114150 )

• no viable homozygous pups are recovered at birth

hematopoietic system

abnormal blood cell morphology/development ( J:114150 )

• common myeloid progenitors (CMPs) and granulocyte/macrophaged progenitors (GMPs) are undetectable in fetal liver at E14.5 while megakaryocyte/erythrocyte progenitors (MEPs) are relatively increased

decreased hematopoietic stem cell number ( J:114150 )

• number of fetal hematopoietic stem cells (HSCs) in fetal liver is reduced 10-fold compared with wild-type at E14.5

abnormal hematopoietic system physiology ( J:114150 )

• fetal liver cells can home to the bone marrow when transplanted into lethally-irradiated hosts, but cannot maintain HSC pool or contribute to myelopoiesis or lymphopoiesis