Phenotypes Associated with This Genotype

Genotype
MGI:3688404

• Allelic Composition: Cd274^tm2Shr/Cd274^tm2Shr
• Genetic Background: involves: 129/Sv * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:113851 )

• upon stimulation with L. mexicana antigen for 4 days, inguinal lymph node cells show a decrease in CD4+ Il-4 producing cells compared to wild-type

• qIfng/Il-4 ratio is significantly increased compared to wild-type

decreased susceptibility to parasitic infection ( J:113851 )

• by 9 weeks, mice develop markedly smaller lesions (5 mm) compared to wild-type (9 mm) upon subcutaneous inoculation with L. mexicana

• parasitic burden is reduced 100-fold compared to wild-type

• inflammation is substantially reduced with fewer parasitized macrophages and absence of tissue damage compared to wild-type