Phenotypes Associated with This Genotype

Genotype
MGI:3688387

• Allelic Composition: Abcg5^tm1Plo/Abcg5^tm1Plo
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:112995 )

• basal biliary sterol secretion rates are decreased by 82%

• basal biliary phospholipid secretion rates are decreased by 35%

abnormal cholesterol homeostasis ( J:112995 )

• expression of cholesterol metabolism genes in the liver is altered

liver/biliary system

increased liver weight ( J:112995 )

• liver weights are slightly increased, however this is not due to steatosis as triglyceride levels are not increased

abnormal bile secretion ( J:112995 )

• basal biliary sterol secretion rates are decreased by 82%

• basal biliary phospholipid secretion rates are decreased by 35%

• exhibit increased bile flow after the creation of a gallbladder fistula, however bile salt output rates and biliary bile salt composition are unaffected

abnormal liver physiology ( J:112995 )

• 45% reduction in liver sterol ester concentrations

• do not exhibit an increase in sterol secretion when fed the LXR agonist T0901317, as is seen with wild-type

growth/size/body

increased liver weight ( J:112995 )

• liver weights are slightly increased, however this is not due to steatosis as triglyceride levels are not increased