Phenotypes for Isl2 Mnx1 MGI:3688256 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mnx1^tm1Jhk/Mnx1^tm1Jhk Isl2^tm2Slp/Isl2^tm2Slp
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl2^tm2Slp mutation (1 available); any Isl2 mutation (28 available)
Mnx1^tm1Jhk mutation (1 available); any Mnx1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:89755 )

• frequently observe inappropriate axonal bridges between segmentally arrayed motor nerves indicating defects in motor axon guidance

abnormal motor neuron morphology ( J:89755 )

• exhibit a complete absence of Nos1+ preganglionic motor column neurons

abnormal motor neuron innervation pattern ( J:89755 )

• exhibit motor axon projections into the periphery

cellular

abnormal axon guidance ( J:89755 )

• frequently observe inappropriate axonal bridges between segmentally arrayed motor nerves indicating defects in motor axon guidance

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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