Phenotypes Associated with This Genotype

Genotype
MGI:3688149

• Allelic Composition: Fgr^Mhdaali18/Fgr⁺
• Genetic Background: C3HeB/FeJ-Fgr^Mhdaali18

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Morphologic appearance of feet and tail of Fgr^Mhdaali18/Fgr^Mhdaali18 and Fgr^Mhdaali18/Fgr^Mhdaali18+ mice.

limbs/digits/tail

abnormal digit morphology ( J:112868 )

• swollen and/or red hindfoot toes at about 7 weeks of age

abnormal foot pad morphology ( J:112868 )

• Background Sensitivity: mice on a mixed background that includes C3HeB/FeJ and either BALB/c, C57BL/6J, or CAST/EiJ do not show any paw swelling

• swollen and/or red hindfoot pads at about 7 weeks of age; however forepaws are rarely affected

• maintenance of mice in either conventional or specific pathogen free conditions does not affect the phenotype

• penetrance of this phenotype is incomplete but increases with age alomg with severity each reaching maximal levels around 13 weeks of age

immune system

increased inflammatory response ( J:112868 )

• mild inflammation of the bone marrow and mice become arthritic by 13 weeks of age; however, no inflammation is detected in the articular joints, synovium, or periosteum

dermatitis ( J:112868 )

• mild inflammation of the skin region of swollen paws

integument

dermatitis ( J:112868 )

• mild inflammation of the skin region of swollen paws