Phenotypes Associated with This Genotype

Genotype
MGI:3688147

• Allelic Composition: Gabbr1^tm4Bet/Gabbr1^tm4Bet
• Genetic Background: BALB/c-Gabbr1^tm4Bet

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal conditioned taste aversion behavior ( J:111889 )

• increased retention of aversion to saccharin containing water when LiCl treatment is paired with saccharin exposure (over 30 days compared to about 5 days in wild-type mice)

nervous system

abnormal inhibitory postsynaptic currents ( J:113340 )

• in CA1 pyramidal cells at a holding potential of -50 mV with physiological extracellular K+ concentrations outward currents elicited by baclofen are reduced by about 60% compared to wild-type cells

• however, long term potentiation of CA3 to CA1 synapses, baclofen-induced depression of EPSC amplitudes, and the amplitude ratio of evoked EPSCs in response to paired-pulse stimulation are similar to wild-type