Phenotypes Associated with This Genotype

Genotype
MGI:3687999

• Allelic Composition: Tg(Sod1*G86R)M1Jwg/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:59356 )

• die between 105 and 140 days of age

behavior/neurological

paralysis ( J:59356 )

• limb paralysis

vision/eye

short retina rod cell outer segment ( J:59356 )

• light exposed eyes show shortening of the rod outer segments relative to the rod inner segments

retina photoreceptor degeneration ( J:59356 )

• exposure to constant bright light for 20 days causes specific degeneration of photoreceptor cells

thin retina outer nuclear layer ( J:59356 )

• light exposed eyes show a decrease in the thickness of the retinal outer nuclear layer due to loss of photoreceptor cells compared to controls

abnormal eye electrophysiology ( J:59356 )

• exposure to constant bright light for 20 days causes a diminution of electroretinographic activity

nervous system

short retina rod cell outer segment ( J:59356 )

• light exposed eyes show shortening of the rod outer segments relative to the rod inner segments

retina photoreceptor degeneration ( J:59356 )

• exposure to constant bright light for 20 days causes specific degeneration of photoreceptor cells