Phenotypes Associated with This Genotype

Genotype
MGI:3687995

• Allelic Composition: Tg(SOD1*G86R)M3Jwg/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

aphagia ( J:22628 )

• cease food and water intake

abnormal motor capabilities/coordination/movement ( J:22628 )

• develop generalized loss of motor activity

weakness ( J:22628 )

• develop a generalized weakness by 100 days of age

hindlimb paralysis ( J:22628 )

• develop progressive spastic paralysis of the left hind limb and flank at about 100 days of age

nervous system

motor neuron degeneration ( J:22628 )

• exhibit degenerative changes of motor neurons within the spinal cord, brain stem, and neocortex

abnormal spinal cord ventral horn morphology ( J:22628 )

• exhibit degenerative changes within the ventral horn