Phenotypes Associated with This Genotype

Genotype
MGI:3687986

• Allelic Composition: Me1ⁿ/Me1ⁿ
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:6579 )

N • number of homozygous females (~33%) is lower than expected (~50%), possibly indicating a detrimental effect of the mutant allele, expressed early in development

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:6579 )

• mice have very low cytoplasmic malic enzyme activity (<0.10) compared to wild-type homozygous for the DBA/2J (variant a) form (1.10) or the C57BL/6J (variant b) form (0.50)