Phenotypes Associated with This Genotype

Genotype
MGI:3687957

• Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:60897 )

• embryos arrest soon after implantation

embryo

embryonic growth arrest ( J:60897 )

• embryos arrest soon after implantation and fail to form embryonic or extraembryonic structures (examined at E6 and E7.5)

abnormal egg cylinder morphology ( J:60897 )

• in chimeras with wild-type tetraploids, embryos still resemble enlarged egg cylinders without mesoderm at E8.5

absent mesoderm ( J:60897 )

• in chimeras with wild-type tetraploids, posterior thickening of epiblast occurs with signs of epithelial to mesenchymal transition but no embryonic or extraembryonic mesoderm

abnormal anterior primitive streak morphology ( J:60897 )

• differentiation of anterior streak and node is blocked

absent primitive node ( J:60897 )

• in chimeras with wild-type tetraploids, a distinct node is absent at E7.5

abnormal primitive streak elongation ( J:60897 )

• in chimeras with wild-type tetraploids, elongation of the primitive streak is absent at E7.5

abnormal trophoblast layer morphology ( J:60897 )

• no trophoblast outgrowth from cultured blastocysts