Phenotypes Associated with This Genotype

Genotype
MGI:3687871

• Allelic Composition: Vax2^tm1Grl/Vax2^tm1Grl
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:74240 )

• about 7% are overtly abnormal displaying reduced body size, tremors, or small eyes

growth/size/body

decreased body size ( J:74240 )

• about 7% are overtly abnormal displaying reduced body size, tremors, or small eyes

nervous system

abnormal axon guidance ( J:74240 )

• expression gradients of axon guidance cues along the nasotemporal axis are flattened or absent; however dorsoventral gradients are maintained

• severity of the dorsalization of the retinal ganglion cell axons becomes less severe in increasingly nasal sections along the nasotemporal axis with termination zones very near the expected location in the most nasal locations

abnormal optic nerve innervation ( J:74240 )

• dorsal retinal ganglion cell axons project normally; however ventral axon projections are abnormal with axons from the ventral temporal retina most strongly affected

• ventral temporal axons enter the superior colliculus at the lateral rostral edge and form a single termination zone in the lateral rostral superior colliculus rather than in the medial rostal superior colliculus

• severity of the dorsalization of the retinal ganglion cell axons becomes less severe in increasingly nasal sections along the nasotemporal axis with termination zones very near the expected location in the most nasal locations

vision/eye

abnormal optic nerve innervation ( J:74240 )

• dorsal retinal ganglion cell axons project normally; however ventral axon projections are abnormal with axons from the ventral temporal retina most strongly affected

• ventral temporal axons enter the superior colliculus at the lateral rostral edge and form a single termination zone in the lateral rostral superior colliculus rather than in the medial rostal superior colliculus

• severity of the dorsalization of the retinal ganglion cell axons becomes less severe in increasingly nasal sections along the nasotemporal axis with termination zones very near the expected location in the most nasal locations

microphthalmia ( J:74240 )

• about 7% are overtly abnormal displaying reduced body size, tremors, or small eyes

• however, no mice display coloboma

cellular

abnormal axon guidance ( J:74240 )

• expression gradients of axon guidance cues along the nasotemporal axis are flattened or absent; however dorsoventral gradients are maintained

• severity of the dorsalization of the retinal ganglion cell axons becomes less severe in increasingly nasal sections along the nasotemporal axis with termination zones very near the expected location in the most nasal locations