Phenotypes for Ctnnb1 Tg(Col2a1-cre)1Bhr MGI:3687748 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1.1Yy mutation (0 available); any Ctnnb1 mutation (47 available)
Ctnnb1^tm1Yy mutation (0 available); any Ctnnb1 mutation (47 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased chondrocyte apoptosis ( J:112462 )

• exhibit extensive cell death in both proliferative and resting chondrocytes at E18.5

skeleton

increased chondrocyte apoptosis ( J:112462 )

• exhibit extensive cell death in both proliferative and resting chondrocytes at E18.5

abnormal perichondrium morphology ( J:112462 )

• perichondrium is thinner

decreased bone mineralization ( J:112462 )

• mineralization is decreased

failure of bone ossification ( J:112462 )

• ossification is inhibited

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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