Phenotypes Associated with This Genotype

Genotype
MGI:3687747

• Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy; Ptch1^tm1Yy/Ptch1^tm1.1Yy; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

arrested osteoblast differentiation ( J:112462 )

• osteoblast differentiation is severely blocked and mature osteoblasts are almost completely absent in E16.5 embryo limbs

skeleton

arrested osteoblast differentiation ( J:112462 )

• osteoblast differentiation is severely blocked and mature osteoblasts are almost completely absent in E16.5 embryo limbs

abnormal elbow joint morphology ( J:112462 )

• the elbow joint interzone fails to form

abnormal long bone hypertrophic chondrocyte zone ( J:112462 )

• chondrocyte hypertrophy is inhibited

fused synovial joints ( J:112462 )

• show extensive synovial joint fusions which are much more severe than in each of the single mutants

abnormal perichondrium morphology ( J:112462 )

• perichondrium is thinner

decreased bone mineralization ( J:112462 )

• mineralization in the long bones is more severely reduced than in single conditional Ctnnb1 mutants

delayed endochondral bone ossification ( J:112462 )

• ossification is more severely inhibited than in single conditional Ctnnb1 mutants

craniofacial

craniofacial phenotype ( J:112462 )

N • exhibit normal posterior skull formation

limbs/digits/tail

abnormal elbow joint morphology ( J:112462 )

• the elbow joint interzone fails to form