Phenotypes for Ptch1 Tg(Col2a1-cre)1Bhr MGI:3687745 MGI Mouse

abnormal osteoblast differentiation ( J:112462 )

• exhibit ectopic osteoblast differentiation in the perichondrium

• exhibit delayed osteoblast maturation as none is seen at E14.5 but is seen at E16.5

increased chondrocyte proliferation ( J:112462 )

• chondrocyte proliferation in the presumed resting zone is significantly increased

abnormal cranium morphology ( J:112462 )

• posterior skull fails to form

abnormal long bone hypertrophic chondrocyte zone ( J:112462 )

• in the humerus, chondrocyte hypertrophy is missing yet osteoblast differentiation occurs at E16.5; chondrocyte hypertrophy does occur in the radius, ulna and tibia

decreased length of long bones ( J:112462 )

• long bones in the limb are shorter

fused synovial joints ( J:112462 )

• exhibit mild synovial joint fusion in embryos, such as the fusion of the radius and ulna with the carpel bones

abnormal bone ossification ( J:112462 )

• exhibit extensive and ectopic ossification at joints

abnormal bone mineralization ( J:112462 )

• bone mineralization is enhanced

• mineralized periosteum extends ectopically to the joint region where mineralization is never seen in wild-type