Phenotypes Associated with This Genotype

Genotype
MGI:3687260

• Allelic Composition: Tasp1^tm1.1Jjdh/Tasp1^tm1.1Jjdh
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:112159 )

• most die during day 1 or day 2 postnatally

• only about 13% survive to weaning

prenatal lethality, incomplete penetrance ( J:112159 )

• only about 89% of expected homozygotes are born

behavior/neurological

abnormal suckling behavior ( J:112159 )

• no indication that pups dying within the first 2 days of life ever suckle

growth/size/body

decreased embryo size ( J:112159 )

• first noticeable at E14.5

• significantly smaller than normal at E18.5

decreased body size ( J:112159 )

• markedly smaller than normal immediately after birth

skeleton

abnormal sternebra morphology ( J:112159 )

• incomplete segmentation between sternebrae 3 and 4

increased rib number ( J:112159 )

• 14 pairs of ribs; additional pair of sternal ribs

abnormal vertebrae morphology ( J:112159 )

abnormal cervical vertebrae morphology ( J:112159 )

abnormal arcus anterior morphology ( J:112159 )

• anterior arch of the atlas is broadened and tilted anteriorly

abnormal cervical axis morphology ( J:112159 )

• split neural arch of the axis

vertebral transformation ( J:112159 )

thoracic vertebral transformation ( J:112159 )

• anterior transformation of T8 to T7 with resulting additional sternal ribs

cervical vertebral transformation ( J:112159 )

• posterior transformation of C7 to T1 with attached aberrant ribs

lumbar vertebral transformation ( J:112159 )

• anterior transformation of L1 to T13

cellular

decreased cell proliferation ( J:112159 )

• delayed entry of embryonic fibroblasts into the S phase of the cell cycle

embryo

decreased embryo size ( J:112159 )

• first noticeable at E14.5

• significantly smaller than normal at E18.5