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Phenotypes Associated with This Genotype
Genotype
MGI:3687248
Allelic
Composition		 Ightm2Cgn/Igh+
Rr158tm1Cgn/Rr158tm1Cgn
Arhgef1tm1.1Rmt/Arhgef1tm1.1Rmt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef1tm1.1Rmt mutation (0 available); any Arhgef1 mutation (73 available)
Ightm2Cgn mutation (1 available); any Igh mutation (41 available)
Rr158tm1Cgn mutation (0 available); any Rr158 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal B cell migration ( J:113295 )
• increase in the proportion of cells that migrate towards high sphingosine 1-phosphate (S1P) concentrations
• reduction in migratory response towards S1P induced by LPS treatment is decreased compared to wild-type
• immunization with a low dose of T cell dependent antigen (NP-CG) fails to suppress responsiveness to S1P unlike in wild-type mice; however, treatment with a high concentration of antigen does reduce S1P responsiveness

immune system
abnormal B cell migration ( J:113295 )
• increase in the proportion of cells that migrate towards high sphingosine 1-phosphate (S1P) concentrations
• reduction in migratory response towards S1P induced by LPS treatment is decreased compared to wild-type
• immunization with a low dose of T cell dependent antigen (NP-CG) fails to suppress responsiveness to S1P unlike in wild-type mice; however, treatment with a high concentration of antigen does reduce S1P responsiveness

hematopoietic system
abnormal B cell migration ( J:113295 )
• increase in the proportion of cells that migrate towards high sphingosine 1-phosphate (S1P) concentrations
• reduction in migratory response towards S1P induced by LPS treatment is decreased compared to wild-type
• immunization with a low dose of T cell dependent antigen (NP-CG) fails to suppress responsiveness to S1P unlike in wild-type mice; however, treatment with a high concentration of antigen does reduce S1P responsiveness

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory