Phenotypes Associated with This Genotype

Genotype
MGI:3687171

• Allelic Composition: Aptx^tm1Pmc/Aptx^tm1Pmc
• Genetic Background: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal DNA repair ( J:170077 )

• following exposure to methylmethanesulphonate, astrocytes exhibit short-patch repair compared with wild-type cells

abnormal single-strand DNA break repair ( J:145730 )

• astrocytes fail to support short-patch repair of adenylated oxidative single strand breaks unlike wild-type cells

• following treatment with hydrogen peroxide and aphidicolin, single strand break repair in astrocytes is slowed compared to in similarly treated wild-type cells

• however, primary quiescent astrocytes and cerebellar granule neurons treated with MMS or hydrogen peroxide exhibit normal single strand break repair

homeostasis/metabolism

abnormal DNA repair ( J:170077 )

• following exposure to methylmethanesulphonate, astrocytes exhibit short-patch repair compared with wild-type cells

abnormal single-strand DNA break repair ( J:145730 )

• astrocytes fail to support short-patch repair of adenylated oxidative single strand breaks unlike wild-type cells

• following treatment with hydrogen peroxide and aphidicolin, single strand break repair in astrocytes is slowed compared to in similarly treated wild-type cells

• however, primary quiescent astrocytes and cerebellar granule neurons treated with MMS or hydrogen peroxide exhibit normal single strand break repair