About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3687028
Allelic
Composition		 H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic
Background		 NOD.Cg-Rag1tm1Mom H2-Ab1b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Gru mutation (13 available); any H2-Ab1 mutation (81 available)
Rag1tm1Mom mutation (56 available); any Rag1 mutation (132 available)
Tg(HLA-DQA1,HLA-DQB1)73Myl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
myocarditis ( J:88055 )
• mice do not develop spontaneous myocarditis like NOD.B6-H2Ab1tm1Gru-Tg(HLA-DQA1,HLA-DQB1)73 mice

immune system
myocarditis ( J:88055 )
• mice do not develop spontaneous myocarditis like NOD.B6-H2Ab1tm1Gru-Tg(HLA-DQA1,HLA-DQB1)73 mice
abnormal response to transplant ( J:88055 )
• injection of splenocytes from myocarditis-affected donors into healthy transgenic mice results in acute onset of symptoms of severe heart failure 3 weeks post-transfer, reproducing symptoms of the donor mice
• injection of serum from diseased donors with high autoantibody titer does not result in myocarditis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory